姓名 吕心游
职称 特任研究员
所属单位 心理学系
主要专业方向 精神心理学,神经生物学,神经调控
个人简介:
吕心游,神经生物学博士,中国科学技术大学心理学系特任研究员,博士生导师,中国药物滥用防治协会成瘾与脑科学分会委员。2018年毕业于浙江大学医学院,获得神经生物学博士学位。此后在上海交通大学医学院从事博士后研究。主要关注两个方向的研究:1药物成瘾和行为成瘾的认知神经可塑性机制与干预,旨在挖掘成瘾引起认知心理与脑的神经可塑性变化的关系,并以此为靶点开发干预药物成瘾的新范式;2社会心理行为的脑机制,通过结合动物和人的研究,发现编码社会心理行为的脑网络与神经环路模式。入选上海交通大学医学院博士后激励计划,获国自然青年基金、上海市青年英才扬帆计划等资助。
代表性论文:
· Lv X, Zhang J, Yuan T. Retrieval-Extinction of drug memory requires AMPA receptor trafficking. Sci Adv. 2022,8(51):eadd6642.
· Wang J#, Lv X#, Wu Y, Xu T, Jiao M, Yang R, Li X, Chen M, Yan Y, Chen C, Dong W, Yang W, Zhuo M, Chen T*, Luo J*, Qiu S*. Postsynaptic RIM1 modulates synaptic function by facilitating membrane delivery of recycling NMDARs in hippocampal neurons. Nat Commun. 2018,9(1):2267. (#co-first author)
· Wang Y#, Lv X#, Liu M#, Wang J, Zuo Z, Wu C, Liu L, Chen W, Qiu S, Xu T, Zhang C, Feng Z*, Li X*. Deficits of apoptosis related protein 3 cause peripheral hypersensitivity andimpair long-term objects memory. (#co-first author) (submitted)
· Wu Y, Lv X, Wang H, Qian K, Ding J, Wang J, Hua S, Sun T, Zhou Y, Yu L, Qiu S. Adaptor protein APPL1 links neuronal activity to chromatin remodeling in cultured hippocampal neurons. J Mol Cell Biol. 2021,13(5):335.
· Wu Y#, Chen C#, Chen M#, Qian K, Lv X, Wang H, Jiang L, Yu L, Zhuo M, Qiu S. The anterior insular cortex unilaterally controls feeding in response to aversive visceral stimuli in mice. Nat Commun. 2020,11(1):640.
· Qiu S#, Wu Y#, Lv X, Li X, Zhuo M, Koga K. Reduced synaptic function of Kainate receptors in the insular cortex of Fmr1 Knock-out mice. Mol Brain. 2018,11(1):54.
· Zhang X, Lv X, Tang Y, Zhu L, Luo J. Cysteine residues 87 and 320 in the amino terminal domain of NMDA receptor GluN2A govern its homodimerization but do not influence GluN2A/GluN1 heteromeric assembly. Neurosci Bull. 2013,29(6):671.